Let's start at the beginning...

Antioxidants...We hear the term a lot but why do we need them??

What Are Reactive Oxygen Species (ROS)?

Reactive Oxygen Species (ROS) are chemically reactive molecules containing oxygen. They are naturally produced in the body during normal metabolic processes, particularly within the mitochondria — the “energy factories” of our cells.

Common examples of ROS include:

• Superoxide anion (O₂⁻)

• Hydrogen peroxide (H₂O₂)

• Hydroxyl radicals (OH•)

In controlled amounts, ROS actually play important roles in:

• Cell signalling

• Immune defence

• Tissue repair

However, problems arise when ROS production exceeds the body’s ability to neutralise them.

What Is Oxidative Stress?

Oxidative stress occurs when there is an imbalance between ROS and the body’s antioxidant defence system.

Excess ROS can damage:

• Collagen and elastin fibres – leading to loss of firmness

• Cell membranes – impairing skin barrier function

• Proteins and enzymes – reducing cellular efficiency

• DNA – accelerating cellular ageing

In dermatology, oxidative stress is considered one of the primary drivers of intrinsic ageing (natural ageing) and extrinsic ageing (environmental ageing).

Major contributors to increased ROS in the skin include:

• Ultraviolet (UV) radiation
• Air pollution
• Smoking
• Chronic stress
• Poor nutrition
• Inflammation

Over time, this cumulative damage results in fine lines, pigmentation changes, dullness, dehydration, and reduced elasticity.

The Protective Role of Antioxidants

Antioxidants are molecules that neutralise ROS by donating electrons, stabilising free radicals before they damage healthy tissue.

The body naturally produces antioxidants such as:

• Glutathione

• Superoxide dismutase

• Catalase

However, with age and environmental exposure, our natural antioxidant capacity declines.

This is where targeted skin treatments become important.

How NCTF Supports Cellular Skin Health

NCTF 135HA by Fillmed is formulated to address oxidative stress directly at a dermal level.

It contains:

• Hyaluronic acid for hydration and matrix support

• Vitamins (including A, C, and E) with antioxidant properties

• Amino acids to support protein synthesis

• Co-enzymes essential for cellular metabolism

• Minerals that aid enzymatic repair processes

Scientifically, NCTF works by:

1. Replenishing depleted nutrients within the dermis

2. Enhancing fibroblast activity to stimulate collagen production

3. Improving extracellular matrix quality

4. Supporting antioxidant defence mechanisms

5. Reducing the impact of oxidative stress on skin cells

By improving the biological environment of the skin, we can enhance its ability to repair, regenerate, and maintain structural integrity.

A Proactive Approach to Ageing: Prevention vs Correction: 

While many treatments focus on correcting visible signs of ageing, regenerative treatments such as NCTF aim to:

• Strengthen the skin before significant breakdown occurs

• Improve long-term skin resilience

• Support cellular longevity

• Maintain a natural, healthy appearance